Dr Mark Macdonald

Dr Mark Macdonald is a Consultant Diagnostic Neuroradiologist and expert witness at Guy’s and St Thomas’ NHS Foundation Trust, where he has been in post since 2019. He specialises in the interpretation of complex neuroradiological imaging across adult and paediatric patients, with particular expertise in neuro-oncology, neurovascular imaging, stroke imaging and emergency neuroradiology, alongside a strong interest in the application of artificial intelligence in neuroimaging.

As a senior consultant, Dr Macdonald provides specialist diagnostic imaging for a broad range of neurological conditions, supporting the assessment and management of patients with brain tumours, cerebrovascular disease and other complex neurological disorders. He plays a central role in multidisciplinary team decision-making, regularly contributes second opinions on challenging cases and supervises specialist trainees as part of his clinical practice. His work requires the delivery of accurate, evidence-based imaging interpretation to support timely diagnosis and treatment planning across both routine and emergency settings.

In addition to his clinical responsibilities, Dr Macdonald contributes to neuro-oncology research through advanced imaging evaluation for novel therapies and is involved in the development of artificial intelligence applications to enhance diagnostic practice. His combination of specialist clinical expertise, leadership within multidisciplinary services and commitment to innovation has established him as an experienced authority in diagnostic neuroradiology.

Dr Mark Macdonald has undertaken medico-legal work since 2024, providing independent expert opinion in Clinical Negligence claims. He accepts instructions on behalf of claimants and prepares clear, balanced and evidence-based reports addressing screening, breach of duty and causation issues. His medico-legal practice focuses on cases requiring specialist neuroradiological opinion, particularly those involving complex neurological imaging, including neuro-oncology, neurovascular conditions, stroke imaging and emergency neuroradiology. Drawing on his expertise in interpreting advanced neuroradiological investigations across adult and paediatric patients, Dr Macdonald is able to provide objective analysis of imaging findings within the context of alleged clinical negligence. He has completed formal expert witness training, ensuring his reports are prepared in accordance with the standards expected for medico-legal practice and are tailored to assist solicitors and the courts.

Dr Macdonald’s clinical practice is centred on the interpretation of complex neuroradiological imaging for both adult and paediatric patients, supporting the diagnosis and management of a wide range of neurological conditions. A significant proportion of his work involves advanced imaging for patients with brain tumours, cerebrovascular disease and acute neurological presentations, where accurate image interpretation is essential to guide treatment decisions and multidisciplinary care.

He has particular expertise in neuro-oncology, including the assessment of primary and secondary brain tumours and imaging evaluation within clinical research trials. His practice also encompasses neurovascular imaging for conditions such as stroke and vascular abnormalities, together with emergency neuroradiology, providing rapid specialist assessment of acute neurological pathology. In addition, he regularly reviews complex and challenging imaging studies, offering second opinions to support diagnostic accuracy and patient management. Alongside his clinical responsibilities, Dr Macdonald has a strong interest in the development and application of artificial intelligence within neuroimaging, contributing to advances in diagnostic imaging techniques and their integration into contemporary clinical practice.

Dr Macdonald contributes to neuro-oncology research through advanced imaging evaluation for novel therapies and is actively involved in the development of artificial intelligence applications in neuroimaging. He also supervises specialist trainees and has published within his field, reflecting his ongoing commitment to research, education and the advancement of diagnostic neuroradiology.