Dr Francesco Manfredonia

Dr Francesco Manfredonia is a Consultant Neurologist and Neurophysiologist and expert witness at The Royal Wolverhampton NHS Trust, where he has served as a Consultant Neurologist since 2009. His principal areas of clinical expertise include epilepsy and seizure disorders, complex neurophysiology, movement disorders, multiple sclerosis, neuroimmunology, neuromuscular disorders and complex headache disorders, with particular expertise in advanced EEG and EMG diagnostics.

With more than 20 years of clinical practice across the UK and Italy, Dr Manfredonia provides specialist assessment and management of adults with a broad spectrum of neurological disorders. His day-to-day practice encompasses dedicated epilepsy services, including first seizure assessment and prolonged video-ambulatory EEG monitoring, alongside complex electrodiagnostic investigations such as EMG and nerve conduction studies for peripheral nerve injuries and neuromuscular conditions. He also provides acute neurophysiology support for emergency, critical care and inpatient services, contributing to the diagnosis and management of patients with complex neurological presentations.

Dr Manfredonia has held senior clinical leadership roles, including Clinical Director for Neurology and Neurophysiology from 2017 to 2025, and currently serves as Epilepsy and Mortality Lead for his department. He complements his clinical practice with academic responsibilities as a Senior Academy Tutor at the University of Birmingham and Senior Editor of Clinical Case Reports. A Fellow of the Royal College of Physicians, he is also a member of the Association of British Neurologists, the British Society of Clinical Neurophysiology and the Italian Society of Neurology and Clinical Neurophysiology. He continues to contribute to the advancement of neurological practice through teaching, specialist neurophysiology expertise and leadership within the field.

Dr Francesco Manfredonia has undertaken medico-legal practice since 2022, accepting instructions in clinical negligence claims. He acts predominantly for claimants and also accepts defendant instructions, providing independent neurological and neurophysiological opinion in cases involving complex neurological disease, epilepsy, neurophysiology and cerebrovascular disorders. His medico-legal practice includes the preparation of screening, breach of duty, causation, combined breach and causation, and condition and prognosis reports.

Dr Manfredonia is particularly well placed to advise on cases involving epilepsy and seizure disorders, stroke, neurodegenerative disease, multiple sclerosis, functional neurological disorders and neuromuscular conditions, together with complex neurophysiological investigations including EEG, EMG and nerve conduction studies. His expertise enables him to provide clear, evidence-based opinions on standards of care, diagnosis, causation and long-term neurological outcome, particularly where specialist neurophysiological interpretation is required. He maintains his medico-legal practice through ongoing specialist training and continuing professional development, ensuring his reports reflect current clinical practice and procedural standards while providing solicitors with clear, balanced and well-reasoned expert opinion.

Dr Manfredonia's clinical practice focuses on the assessment, investigation and management of adults with complex neurological disorders, with particular expertise in epilepsy and clinical neurophysiology. A substantial proportion of his work involves evaluating patients with seizure disorders, including first seizure presentations and non-convulsive status epilepticus, using advanced diagnostic techniques to establish accurate diagnoses and guide ongoing treatment. He also manages patients with stroke, neurodegenerative diseases, multiple sclerosis, functional neurological disorders, complex headache syndromes and neuromuscular conditions.

A key feature of his practice is specialist neurophysiology, where he performs and interprets complex electrodiagnostic investigations, including prolonged video-ambulatory EEG, sleep EEG, EMG and nerve conduction studies. His expertise is applied in the investigation of peripheral nerve injuries, neuromuscular disorders and disorders of the central nervous system, supporting diagnosis in patients with complex or atypical neurological presentations. He also provides acute neurophysiology support for emergency, critical care and inpatient services, enabling timely assessment of patients with severe neurological illness.

Dr Manfredonia combines broad neurological expertise with highly specialised neurophysiological investigation, allowing him to manage both common neurological disorders and complex cases requiring advanced diagnostic interpretation. His practice is underpinned by an evidence-based approach, ensuring patients receive comprehensive assessment and contemporary neurological care across a wide spectrum of conditions.

Dr Manfredonia is an Honorary Senior Clinical Lecturer at the University of Birmingham and Senior Editor of Clinical Case Reports. He has authored more than 20 peer-reviewed publications spanning epilepsy, neuroimaging, multiple sclerosis, demyelinating neuropathies and advanced EEG and EMG methodology. His academic profile is further strengthened by undergraduate and postgraduate teaching, supervision and examiner responsibilities, reflecting his recognised expertise in neurology and clinical neurophysiology.